David Wilson has been placed on the New York Giants' season-ending injured reserve list with a neck injury.
The running back, who has not played since the first week of October, is replaced on the active roster by Andre Brown.
Brown missed the start of the campaign after fracturing his leg during the pre-season, but is expected to feature against the Oakland Raiders this weekend.
Defensive tackle Markus Kuhn has also been activated from the physically unable to perform list, while defensive tackle Shaun Rogers moves to injured reserve.