The San Francisco 49ers have confirmed that Mario Manningham will miss the rest of the season after sustaining a serious knee sprain in Sunday's loss to the Seattle Seahawks.
The wide receiver has torn his posterior and anterior cruciate ligaments.
The 26-year-old will miss the 49ers' final regular season game against the Arizona Cardinals and the playoffs.
Manningham was part of the New York Giants' Super Bowl-winning team last season.
He is the third San Francisco player to sustain a season-ending injury in the last month, joining Kendall Hunter and Kyle Williams.
