Super-bantamweight Carl Frampton will face Kiko Martinez for the second time in 19 months on Saturday night when he attempts to win the IBF title.
The Northern Irishman stopped Martinez in a closely-fought battle in 2013, and it's expected to be another highly competitive contest when they meet in Belfast.
In Ohio, Lucas Matthysse defends his WBC silver light-welterweight title against the unbeaten Roberto Ortiz, while Adrien Broner will be hoping to impress when he fights Emmanuel Taylor.
Below, Sports Mole takes a look at each match while attempting to predict who will prevail from each encounter.
1. Kiko Martinez vs. Carl Frampton
Carl Frampton has long been considered a world champion in waiting, and on Saturday evening, he will get the opportunity to achieve his boyhood dream in front of his loyal supporters in Belfast.
Matches with Scott Quigg and Leo Santa Cruz have, so far at least, fallen by the wayside, and despite winning a WBC eliminator in April, it will be Kiko Martinez's IBF title that will be on the line when he steps through the ropes at the Titanic Quarter.
Martinez is no stranger to Northern Irish fans after he travelled to the country's capital to defend his European belt against Frampton last year, but despite playing his part in a close fight, he was stopped in the ninth by his opponent, but that has since proven to be a blessing in disguise for the Spaniard.
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Two fights later, Martinez won the IBF title after shocking Jhonatan Romero with a sixth-round stoppage in Atlantic City, and after a home defence, he followed that up by travelling to Japan to stop Hozumi Hasegawa in the middle rounds in a fight in which he wasn't winning on any of three scorecards, despite dropping the home fighter in the second.
Many critics have this as a comfortable fight for Frampton, but Martinez has proven himself to be a true world champion. He won the belt away from home, defended it in Spain, before travelling to a country in which he knew he would have to pull out a big performance to return to Europe with his title still intact.
Martinez is regarded as the weakest of the world champions at super-bantamweight, but he has the ability and style that can trouble Frampton, and with the stakes higher, this could be a more cautious fight compared to their previous one.
Frampton has blasted past his previous two opponents but this is a bout that could easily see a number of different outcomes. If Frampton fulfils his potential in this fight, he should be crowned world champion, but he must avoid complacency against an opponent that probably hasn't been given the credit that he deserves in the build-up to this contest.
2. Lucas Matthysse vs. Roberto Ortiz
When Lucas Matthysse destroyed Lamont Peterson in three rounds last year, he appeared to be on the way to a succession of super fights in the light-welterweight division, but after he was out-boxed by Danny Garcia 12 months ago, an opportunity hasn't come his way.
The Argentine was involved in a fight-of-the-year contender against John Molina in April - a bout which saw him hit the canvas twice - but with his edge-of-your-seat, hard-hitting style, fans want to see the 31-year-old in with the major players at 140lbs, or even 147lbs.
Roberto Ortiz is unbeaten in 32 matches in the paid ranks and has spent much of the past three years competing for the WBC silver belt, but he hasn't fought the same calibre of fighters that Matthysse has done and this is seen as a big step up for the Mexican.
Saturday night will also represent his first bout outside of his home country, but regardless of where the fight was taking place, Matthysee would expected to come through with flying colours to potentially set up a lucrative clash with a world champion at the start of next year.
3. Adrien Broner vs. Emmanuel Taylor
Less than 12 months ago, Adrien Broner was being tipped to become the next Floyd Mayweather Jr, but after he was humbled by Marcos Maidana, the brash American has been brought back down to earth as he tries to re-establish his high reckoning within the sport.
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The 25-year-old has gotten himself involved in controversial matters outside the ring, but in it, he hasn't done much to ease the criticism coming his way after he beat Carlos Molina on points in May in a fight that he was expected to make a statement in ahead of future matches at the top end of the light-welterweight division.
Future showdowns with Matthysse and Lamont Peterson have been touted but first of all, Broner must come through against Emmanuel Taylor, who got off the floor to beat Karim Mayfield in his last outing, and deserves respect ahead of the fight in Cincinnati.
Broner, who is a three-weight world champion, should come through comfortably enough, but he needs to win in style, and that means emerging victorious inside the distance against an opponent who hasn't been stopped in his 20-fight career.
Darren Plant
