British heavyweight Anthony Joshua has been ruled of his clash with Kevin Johnson on January 31 due to a back injury.
The 25-year-old, who has won his first 10 fights as a professional inside three rounds, had been due to headline the show at the O2 Arena, but a stress fracture in his back has seen the Olympic gold medallist sidelined for a number of weeks.
Promoter Eddie Hearn told Matchroom Boxing: "It's disappointing to lose Anthony from this great card but after receiving news from the scan, he was left with no option but to rest his back.
"He picked up a niggle in the Sprott camp and had a good month rest after but it hasn't been 100% in camp and the results gave him no option.
"He hopes to resume punching in early February and come back with a bang in Newcastle on April 4."
Kevin Mitchell's eliminator for the WBC lightweight title with Daniel Estrada will now top the bill in London.