Pakistan have set England a target of 238 runs to complete a 4-0 whitewash in the one-day international series between the two nations.
Returning bowler Jade Dernbach was the most productive for England, taking four wickets for 45 runs.
Debutant Danny Briggs also claimed two Pakistani wickets for the cost of 39 runs.
Asad Shafiq top scored for Pakistan, hitting 65 runs of 78 deliveries before he was bowled out by Tim Bresnan.