England have set Pakistan a target of just 217 to win the first one-day international in Abu Dhabi.
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Eoin Morgan won the toss and opted to bat, but Pakistan flourished in the field as a 133-run fourth-wicket Morgan-James Taylor stand was the only ray of light for the tourists.
Mohammad Irfan claimed the first wicket of the day with just the second ball when he beat Jason Roy (0) and upset the opener's off stump.
In came Joe Root, but he did not trouble the scoreboard either as an Anwar Ali delivery in the next over trapped him lbw. Root reviewed the decision, but replays showed that the ball was clipping leg stump.
England's first three batsmen had all gone by the 19th ball of the innings as Alex Hales edged an Ali ball to Younis Khan, but then Morgan (76) and Taylor (60) put on England's biggest-ever fourth-wicket ODI partnership in Asia.
Both men passed 50 before Shoaib Malik claimed their wickets, with Jos Buttler (1) run out in between courtesy of Ali's quick work at mid-wicket.
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Yasir Shah took the wicket of Moeen Ali (7) thanks to a fine one-handed catch high to his left by Babar Azam. Adil Rashid then chipped an Irfan delivery to Pakistani sub Zafar Gohar after also making seven.
Chris Woakes (33 not out) and David Willey (13) provided some resistance for the ninth wicket, but boundaries were hard to come by as Pakistan bowled England out for 216 in the final over.
