Saint-Etienne have replaced Max Gradel, who recently signed for Bournemouth, with on-loan Paris Saint-German forward Jean-Christophe Bahebeck for their first-leg Europa League knockout match against Milsami.
Former Tottenham Hotspur defender Benoit Assou-Ekotto lines out for the French side at full-back.
Benjamin Corgnet starts in midfield against Moldovan champions Milsami, in Saint-Etienne's other change from the side that beat Targu Mures 3-0 in the second leg of the third qualifying round.
Cristian Bud starts up front for Milsami, in place of club captain Romeo Surdu who fails to make the bench.
Milsami: Mitu; Rassulov, Shedrack, Racu, Rhaili; Erhan, Patras, Banovic, Cojacari; Belak; Bud
Subs: Bantis, Gheti, Zarichnyuk, Antoniuc, Silvca, Bolohan, Lendric
Saint-Etienne: Ruffier; Theophile-Catherine, Sall, Pogba, Assou-Ekotto; Corgnet, Lemoine, Diomande, Bahebeck; Roux, Hamouma
Subs: Moulin, Pajot, Clement, Bamba, Brison, Monnet-Paquet, Clerc