AC Milan vs. Lazio (Saturday, 2.00pm)
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Two major rivals for a top-four finish in Serie A convene on Saturday afternoon at San Siro, as faltering AC Milan host second-placed Lazio.
Following a disappointing draw in midweek, Milan sit sixth with five games to go, while their capital-city counterparts have soared through the pack with seven wins from their last 10 league matches.
We say: AC Milan 1-1 Lazio
Lazio have won nine of their 16 away games in Serie A this season, but a trip to San Siro presents its own unique challenge, and they may have to settle for a draw on this occasion.
Simply scoring against the Rome club is something to be celebrated, such is their clean-sheet record, but Milan need more than single-point returns if they are to finish in Italy's top four.
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Roma vs. Inter Milan (Saturday, 5.00pm)
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After a six-goal success pulled them clear of top-four rivals Roma in midweek, Saturday's clash in the capital sees Inter Milan aiming to maintain their form at the Giallorossi's expense.
Inter have won each of their last four games to recover from a dire run in Serie A and secure a spot in the Champions League semi-finals; meanwhile, their hosts have taken one point from the last nine available to slip behind in pursuit of a place inside Italy's top four.
We say: Roma 0-1 Inter Milan
With seven wins and six losses to their name on the road this season - while conceding plenty of goals in the process - Inter have not travelled well throughout this Serie A season.
However, they are apparently running into form at just the right moment. As Roma rarely concede much at the Olimpico, a single goal could therefore separate the sides on Saturday.
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Cremonese vs. Spezia (Saturday, 7.45pm)
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Having slipped to within a whisker of the Serie A relegation zone with only five games remaining, Spezia are in desperate need of victory when they lock horns with Cremonese on Saturday evening.
The Aquilotti will arrive at Stadio Giovanni Zini with their hosts even more precariously placed despite drawing with Milan, and defeat for the Grigiorossi would surely mean a swift return to the second tier.
We say: Cremonese 2-1 Spezia
Having demonstrated the more convincing form of these two strugglers, Cremonese can build on their near-miss in Milan and keep their fight for survival alive. Victory would take them within four points of their ailing visitors; setting up an almighty scrap in the final four rounds.