AFC Wimbledon vs. Grimsby Town (Saturday, 12.30pm)
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AFC Wimbledon will be looking to extend their unbeaten run in League Two to seven matches when they face Grimsby Town on Saturday.
The visitors, on the other hand, have not won any of their last five league games.
We say: AFC Wimbledon 0-1 Grimsby Town
Grimsby are bound to win in League Two sooner rather than later, and they showed their prowess on the road once again last weekend by stunning Cambridge in the FA Cup.
Wimbledon have been on a strong run recently, but we have a sneaky feeling their unbeaten run may be coming to an end on Saturday.
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Gillingham vs. Salford City (Saturday, 12.30pm)
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Two teams that are desperate for points for vastly different reasons will meet on Saturday as Gillingham's search to get out of the relegation zone continues.
While the Gills are pushing to escape the bottom two, Salford City could be back in the playoff positions with three points at the weekend.
We say: Gillingham 0-2 Salford City
Gillingham have been stronger at home than on the road this season, but despite having that improved form it is still unlikely that they will take three points this weekend.
Salford City must get back to winning ways in the league to keep the pressure on the other teams pushing for promotion, and that is what they should be able to do here.
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Leyton Orient vs. Bradford (Saturday, 12.30pm)
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It is a top-of-the-table clash on Saturday as League Two leaders Leyton Orient welcome fifth-placed Bradford City in what promises to be a thrilling encounter.
The Bantams are without a victory in their previous two matches in all competitions though, while the hosts head into this following consecutive wins.
We say: Leyton Orient 1-1 Bradford City
This is set to be a tense fixture between two of the strongest teams in League Two so far, with Leyton Orient being a dominant team while Bradford City are strong away from home.
Both are able to bring great attacking quality to the forefront, but seeing them battle out a draw would not be a huge surprise.
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Carlisle vs. Sutton (Saturday, 1.00pm)
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Both teams will be looking to make it consecutive victories in League Two when Carlisle United host Sutton United on Saturday.
The hosts could move as high as fourth in the table with a win, but Sutton are languishing in the bottom half.
We say: Carlisle United 2-1 Sutton United
Despite Carlisle heading into this fixture 10 points clear of their opponents, we expect a closely-fought affair in Cumbria on Saturday.
However, Simpson is building something special during his second spell there, and his side should just edge past Sutton.
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Crawley vs. Swindon (Saturday, 3.00pm)
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Crawley Town will attempt to get back to winning ways in League Two this weekend, when they take on Swindon Town at the People's Pension Stadium on Saturday.
The hosts arrive off the back of a draw with Gillingham, while the visitors make the trip with a point to prove following a defeat against Crewe Alexandra last time out.
We say: Crawley Town 1-2 Swindon Town
In a match that could hold significance at both ends of the table, we expect an open affair between two sides with a point to prove this weekend.
Crawley will put in an improved display on recent showings, however, it will not be enough to prevent Swindon from claiming all three points.
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Hartlepool vs. Stockport (Saturday, 3.00pm)
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Basement battlers Hartlepool United will attempt to get back to winning ways in League Two this weekend, when they take on Stockport County at the Suit Direct Stadium on Saturday.
The hosts come into this one off the back of a defeat to Barrow, while the visitors travel to County Durham following a loss to Leyton Orient at home.
We say: Hartlepool United 1-1 Stockport County
In a match with permutations in the lower half of the division, we expect both sides to go full throttle as they seek some much needed momentum.
On this occasion, it will be impossible to pick the teams apart, leaving them with a point apiece in this League Two encounter.
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Mansfield vs. Colchester (Saturday, 3.00pm)
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Mansfield Town will be looking to move into the League Two playoff places with a win against Colchester United at the One Call Stadium on Saturday.
The visitors have more modest expectations this season, and need to start picking up more points to put distance between themselves and the relegation zone.
We say: Mansfield Town 2-1 Colchester United
Mansfield have been in poor form in recent weeks, but this game serves as a good opportunity to get their season back on track. The Stags do not have a great defensive record, so they may concede, but they should have too much quality for Colchester to contend with.
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Northampton vs. Tranmere (Saturday, 3.00pm)
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Northampton Town could cement their place in the automatic promotion spots even further with a victory against Tranmere Rovers at Sixfields Stadium on Saturday afternoon.
The visitors will be looking to make up lost ground on the League Two playoff places, starting proceedings five points off the top seven, in 12th.
We say: Northampton Town 2-0 Tranmere Rovers
Tranmere have not been at the races in recent weeks and should succumb to a defeat on the road against one of the division's best sides. Northampton have a great chance to make it three wins on the spin, and secure their place in the automatic promotion spots.
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Rochdale vs. Harrogate (Saturday, 3.00pm)
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Two sides struggling at the bottom of League Two meet on Saturday when Rochdale host Harrogate Town at the Crown Oil Arena.
The hosts are seeking to respond to back-to-back defeats in the league, while the visitors crashed out of the FA Cup last weekend.
We say: Rochdale 2-1 Harrogate Town
In their last encounter in League Two, the two sides played out a thrilling 3-3 draw, however, we fancy the home side to take all three points here.
Harrogate Town are without an away win for the past seven league games coming into this one, while the Dale have only conceded three goals in their past three matches on their own turf.