The Arsenal goalkeeper, 23, is said to have aggravated an ankle injury.
Szczesny suffered the problem as the Poles met up for the first time before Friday's encounter with Slovakia in Wroclaw, according to ITV Sport.
The keeper has won 15 caps for his country since making his debut in 2009.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 12 | 10 | 1 | 1 | 24 | 8 | 16 | 31 |
| 2 | Arsenal | 13 | 7 | 4 | 2 | 26 | 14 | 12 | 25 |
| 3 | Manchester CityMan City | 12 | 7 | 2 | 3 | 22 | 17 | 5 | 23 |
| 4 | Brighton & Hove AlbionBrighton | 13 | 6 | 5 | 2 | 22 | 17 | 5 | 23 |
| 5 | Chelsea | 12 | 6 | 4 | 2 | 23 | 14 | 9 | 22 |
| 6 | Nottingham ForestNott'm Forest | 13 | 6 | 4 | 3 | 16 | 13 | 3 | 22 |
| 7 | Brentford | 13 | 6 | 2 | 5 | 26 | 23 | 3 | 20 |
| 8 | Tottenham HotspurSpurs | 12 | 6 | 1 | 5 | 27 | 13 | 14 | 19 |
| 9 | Aston Villa | 12 | 5 | 4 | 3 | 19 | 19 | 0 | 19 |
| 10 | Newcastle UnitedNewcastle | 13 | 5 | 4 | 4 | 14 | 14 | 0 | 19 |
| 11 | Bournemouth | 13 | 5 | 3 | 5 | 20 | 19 | 1 | 18 |
| 12 | Fulham | 12 | 5 | 3 | 4 | 17 | 17 | 0 | 18 |
| 13 | Manchester UnitedMan Utd | 12 | 4 | 4 | 4 | 13 | 13 | 0 | 16 |
| 14 | West Ham UnitedWest Ham | 13 | 4 | 3 | 6 | 17 | 24 | -7 | 15 |
| 15 | Everton | 12 | 2 | 5 | 5 | 10 | 17 | -7 | 11 |
| 16 | Leicester CityLeicester | 13 | 2 | 4 | 7 | 16 | 27 | -11 | 10 |
| 17 | Crystal Palace | 13 | 1 | 6 | 6 | 11 | 18 | -7 | 9 |
| 18 | Wolverhampton WanderersWolves | 13 | 2 | 3 | 8 | 22 | 32 | -10 | 9 |
| 19 | Ipswich TownIpswich | 13 | 1 | 6 | 6 | 13 | 24 | -11 | 9 |
| 20 | Southampton | 13 | 1 | 2 | 10 | 10 | 25 | -15 | 5 |
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