Atalanta vs. Cesena (Wednesday, 5.30pm)
© Imago
Top of the tree in Italy after 10 consecutive league wins, Atalanta BC will switch focus to the Coppa Italia on Wednesday, when they host Cesena in the last 16.
Beaten in last season's final, the Serie A leaders are intent on going one step further this term, while their second-tier opponents aim to cause an almighty shock.
We say: Atalanta BC 3-0 Cesena
The most potent attack in Serie A will meet one of the least effective away sides in Serie B, so Atalanta can surely take care of business.
Even if the hosts significantly rotate their squad, they should still put a halt to Cesena's cup run and safely secure a place in the last eight.
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Roma vs. Sampdoria (Wednesday, 8.00pm)
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After another setback last weekend, crisis club Roma face a potential Coppa Italia banana skin on Wednesday, when they welcome Sampdoria to Stadio Olimpico.
With just four wins apiece, both sides languish just outside the drop zone in their respective league tables, but all the pressure will sit on the hosts' shoulders.
We say: Roma 3-1 Sampdoria
Only victory will do for Roma, who are well behind Serie A's top seven and uncertain of progressing in the Europa League.
The Coppa Italia could prove their only salvation in a dismal campaign, and they can surely see off Samp to book a quarter-final meeting with Milan.