Antoine Griezmann will partner Oliver and Luciano Vietto in the Atletico Madrid attack against Espanyol as they seek to extend their unbeaten run in La Liga.
Full-back Juanfran makes his first start for three weeks after overcoming a thigh problem, while Saul Niguez takes the place of the suspended Gabi.
Espanyol's Victor Sanchez is also ruled out through suspension, paving the way for Abraham Gonzalez to start in a packed midfield.
Felipe Caicedo will operate as a lone striker for the visitors.
Atletico Madrid: Oblak, Godin, Luis, Juanfran, Gimenez; Tiago, Koke, Oliver, Niguez; Griezmann, Vietto
Subs: Moya,Savic, Gamez, Correa, Partey, Torres, Ferreira-Carrasco
Espanyol: Pau; Javi Lopez, Alvaro, Roco; Fuentes, Diop, Abraham, Hernan, Alvarez, Asensio; Caicedo
Subs: Bardi, Duarte, Canas, Jordan, Moreno, Burgui, Sylla