Atletico Madrid have made four changes to the side which drew 0-0 with Astana in the Champions League on Tuesday.
Jose Gimenez is absent from the centre of defence and former Manchester City defender Stefan Savic replaces the Spaniard, while ex-Chelsea defender Filipe Luis returns to the left-back spot in place of Guilherme Siqueira.
Yannick Carrasco comes back into the side as part of a three-man attack as Saul is dropped to the bench, and Jackson Martinez is preferred to Fernando Torres in attack alongside top scorer Antoine Griezmann.
For the visitors, on-loan Barcelona teenager Alen Halilovic starts in midfield, while Miguel Angel Guerrero leads the line.
Atletico Madrid: Oblak; Juanfran, Godin, Savic, Luis; Gabi, Tiago, Koke; Carrasco, Griezmann, Martinez
Subs: Moya, Hernandez, Gamez, O. Torres, Saul, Correa, F. Torres
Sporting Gijon: Cuellar; Lora, Hernandez, Bernardo, Menendez; Alvarez, Mascarell, Perez, Halilovic, Jony; Guerrero
Subs: Garcia, Muniz, Cases, Lopez, Mere, Fraile, Castro