In what will be a rematch of last year's final - which Barca won 3-1 - Luis Enrique's side will face Athletic over two legs later this month.
Elsewhere, Atletico Madrid will face Celta Vigo, while Gary Neville's Valencia take on Las Palmas.
The other tie sees Sevilla up against the only non-La Liga side left in the competition, second-tier outfit Mirandes.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| C | Real Madrid | 36 | 29 | 6 | 1 | 83 | 22 | 61 | 93 |
| 2 | Barcelona | 36 | 24 | 7 | 5 | 74 | 43 | 31 | 79 |
| 3 | GironaGirona | 36 | 23 | 6 | 7 | 75 | 45 | 30 | 75 |
| 4 | Atletico MadridAtletico | 36 | 23 | 4 | 9 | 67 | 39 | 28 | 73 |
| 5 | Athletic Bilbao | 36 | 17 | 11 | 8 | 58 | 37 | 21 | 62 |
| 6 | Real Sociedad | 36 | 15 | 12 | 9 | 49 | 37 | 12 | 57 |
| 7 | Real BetisBetis | 36 | 14 | 14 | 8 | 48 | 43 | 5 | 56 |
| 8 | Villarreal | 36 | 14 | 9 | 13 | 60 | 60 | 0 | 51 |
| 9 | Valencia | 36 | 13 | 9 | 14 | 37 | 40 | -3 | 48 |
| 10 | Getafe | 36 | 10 | 13 | 13 | 41 | 51 | -10 | 43 |
| 11 | AlavesAlaves | 36 | 11 | 9 | 16 | 34 | 45 | -11 | 42 |
| 12 | Sevilla | 36 | 10 | 11 | 15 | 47 | 50 | -3 | 41 |
| 13 | Osasuna | 36 | 11 | 8 | 17 | 40 | 54 | -14 | 41 |
| 14 | Las PalmasLas Palmas | 36 | 10 | 8 | 18 | 32 | 46 | -14 | 38 |
| 15 | Rayo Vallecano | 36 | 8 | 14 | 14 | 29 | 44 | -15 | 38 |
| 16 | Celta Vigo | 36 | 9 | 10 | 17 | 42 | 54 | -12 | 37 |
| 17 | Mallorca | 36 | 7 | 15 | 14 | 29 | 41 | -12 | 36 |
| 18 | CadizCadiz | 36 | 6 | 14 | 16 | 25 | 49 | -24 | 32 |
| R | Granada | 36 | 4 | 9 | 23 | 37 | 70 | -33 | 21 |
| R | Almeria | 36 | 2 | 11 | 23 | 35 | 72 | -37 | 17 |
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