Brazil will be without both Vinicius Junior and Alisson Becker when they travel to Chile for a must-win World Cup qualifier on Thursday night.
Vini Jr was replaced with just over 10 minutes remaining after scoring Real Madrid's second goal in their 2-0 win over Villarreal on Saturday, and subsequently pulled out of the Brazil squad citing a minor neck injury as the cause.
That leaves a wide berth open for a number of players to fight for ahead of the trip to Santiago, as Raphinha and Gabriel Martinelli will be the likeliest candidates to come into the side.
In goal, Alisson's injury was much more clear to see, as the Liverpool stopper was immediately replaced after feeling discomfort in his hamstring following a wayward clearance at the weekend.
Arne Slot confirmed post-match that the 32-year-old will be out for a few weeks at least, meaning he will be unavailable for his national side here, and possibly in November too.
That will hand Ederson a rare opportunity to start in the Brazilian goal, as the Manchester City keeper is in line to win just a 26th cap in this encounter.
Ahead of him, though, could be a slightly changed backline, as Dorival Junior is dealing with more than a couple of injury concerns in defence at present.
Bremer has been ruled out for the season with an ACL tear, while Eder Militao is also unavailable despite featuring briefly for Real Madrid at the weekend.
Therefore, Gabriel Magalhaes is set to start and win his 10th Brazil cap, but the left-back spot alongside him is currently up for grabs with Guilherme Arana nursing an issue of his own.
Alex Telles is back in the squad, Abner could win his first cap or Dorival Junior will opt to switch Danilo over the left flank and start the slightly more experienced and in-form Monaco full-back Vanderson.
Despite Vini Jr's absence, Real Madrid are still set to be well represented in Brazil's frontline, as Rodrygo and Endrick are likely to start here, alongside whoever Dorival Junior opts to bring in to replace the Ballon d'Or favourite.
Richarlison's continued absence means he is not up for consideration, while Gabriel Jesus has been snubbed again after losing his place in the Arsenal team.
Brazil possible starting lineup: Ederson; Danilo, Marquinhos, Gabriel, Alex Telles; Andre, Bruno Guimaraes, Lucas Paqueta; Raphinha, Endrick, Rodrygo
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