The Czech Republic international will miss the clash because he has failed to recover from a calf injury that also ruled him out of Sunday's 2-2 draw with Brentford in the FA Cup.
The absence of Cech will mean that Ross Turnbull will continue between the posts for the Blues.
An ankle problem has also prevented David Luiz from claiming a spot in the Chelsea squad for the encounter.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 12 | 10 | 1 | 1 | 24 | 8 | 16 | 31 |
| 2 | Manchester CityMan City | 12 | 7 | 2 | 3 | 22 | 17 | 5 | 23 |
| 3 | Chelsea | 12 | 6 | 4 | 2 | 23 | 14 | 9 | 22 |
| 4 | Arsenal | 12 | 6 | 4 | 2 | 21 | 12 | 9 | 22 |
| 5 | Brighton & Hove AlbionBrighton | 12 | 6 | 4 | 2 | 21 | 16 | 5 | 22 |
| 6 | Tottenham HotspurSpurs | 12 | 6 | 1 | 5 | 27 | 13 | 14 | 19 |
| 7 | Nottingham ForestNott'm Forest | 12 | 5 | 4 | 3 | 15 | 13 | 2 | 19 |
| 8 | Aston Villa | 12 | 5 | 4 | 3 | 19 | 19 | 0 | 19 |
| 9 | Newcastle UnitedNewcastle | 11 | 5 | 3 | 3 | 13 | 11 | 2 | 18 |
| 10 | Fulham | 12 | 5 | 3 | 4 | 17 | 17 | 0 | 18 |
| 11 | Brentford | 12 | 5 | 2 | 5 | 22 | 22 | 0 | 17 |
| 12 | Manchester UnitedMan Utd | 12 | 4 | 4 | 4 | 13 | 13 | 0 | 16 |
| 13 | Bournemouth | 12 | 4 | 3 | 5 | 16 | 17 | -1 | 15 |
| 14 | West Ham UnitedWest Ham | 11 | 3 | 3 | 5 | 13 | 19 | -6 | 12 |
| 15 | Everton | 12 | 2 | 5 | 5 | 10 | 17 | -7 | 11 |
| 16 | Leicester CityLeicester | 12 | 2 | 4 | 6 | 15 | 23 | -8 | 10 |
| 17 | Wolverhampton WanderersWolves | 12 | 2 | 3 | 7 | 20 | 28 | -8 | 9 |
| 18 | Ipswich TownIpswich | 12 | 1 | 6 | 5 | 13 | 23 | -10 | 9 |
| 19 | Crystal Palace | 12 | 1 | 5 | 6 | 10 | 17 | -7 | 8 |
| 20 | Southampton | 12 | 1 | 1 | 10 | 9 | 24 | -15 | 4 |
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