Two years on from Southampton's shock 1-0 win on Chelsea's turf, the Saints and the Blues reconvene for Tuesday's Premier League battle at Stamford Bridge.
Enzo Maresca's troops came out second best once again on Saturday, falling to a 2-1 loss to Aston Villa, while the visitors were demolished 4-0 by Brighton & Hove Albion, and here Sports Mole rounds up the team news for the two clubs.
CHELSEA vs. SOUTHAMPTON
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CHELSEA
Out: Mykhaylo Mudryk (suspended), Omari Kellyman (thigh), Noni Madueke (thigh), Benoit Badiashile (thigh), Wesley Fofana (thigh), Nicolas Jackson (thigh), Romeo Lavia (thigh), Marc Guiu (thigh), Trevoh Chalobah (back)
Doubtful: None
Sports Mole's predicted XI: Jorgensen; Gusto, Adarabioyo, Colwill, Cucurella; Dewsbury-Hall, Caicedo; Palmer, Fernandez, Sancho; Neto
SOUTHAMPTON
Out: Jan Bednarek (muscle), Lesley Ugochukwu (ineligible), Ross Stewart (calf), Ryan Fraser (calf), Adam Lallana (thigh)
Doubtful: Taylor Harwood-Bellis (ankle)
Sports Mole's predicted XI: Ramsdale; Harwood-Bellis, Bella-Kotchap, Bree; Sugawara, Gronbaek, Downes, Walker-Peters; Fernandes; Onuachu, Sulemana
For data analysis of the most likely results, scorelines and more for this match please click here.