Full-back Marcel Schmelzer has been ruled out with an ankle problem, while attacker Marco Reus has been forced to pull out with an abductor injury.
Mario Gotze will also play no part because he is suffering with the flu.
The news of the trio's withdrawal has come just a day after Bayern Munich midfielder Bastian Schweinsteiger decided to pull out with an ankle complaint.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 11 | 9 | 1 | 1 | 21 | 6 | 15 | 28 |
| 2 | Manchester CityMan City | 11 | 7 | 2 | 2 | 22 | 13 | 9 | 23 |
| 3 | Chelsea | 11 | 5 | 4 | 2 | 21 | 13 | 8 | 19 |
| 4 | Arsenal | 11 | 5 | 4 | 2 | 18 | 12 | 6 | 19 |
| 5 | Nottingham ForestNott'm Forest | 11 | 5 | 4 | 2 | 15 | 10 | 5 | 19 |
| 6 | Brighton & Hove AlbionBrighton | 11 | 5 | 4 | 2 | 19 | 15 | 4 | 19 |
| 7 | Fulham | 11 | 5 | 3 | 3 | 16 | 13 | 3 | 18 |
| 8 | Newcastle UnitedNewcastle | 11 | 5 | 3 | 3 | 13 | 11 | 2 | 18 |
| 9 | Aston Villa | 11 | 5 | 3 | 3 | 17 | 17 | 0 | 18 |
| 10 | Tottenham HotspurSpurs | 11 | 5 | 1 | 5 | 23 | 13 | 10 | 16 |
| 11 | Brentford | 11 | 5 | 1 | 5 | 22 | 22 | 0 | 16 |
| 12 | Bournemouth | 11 | 4 | 3 | 4 | 15 | 15 | 0 | 15 |
| 13 | Manchester UnitedMan Utd | 11 | 4 | 3 | 4 | 12 | 12 | 0 | 15 |
| 14 | West Ham UnitedWest Ham | 11 | 3 | 3 | 5 | 13 | 19 | -6 | 12 |
| 15 | Leicester CityLeicester | 11 | 2 | 4 | 5 | 14 | 21 | -7 | 10 |
| 16 | Everton | 11 | 2 | 4 | 5 | 10 | 17 | -7 | 10 |
| 17 | Ipswich TownIpswich | 11 | 1 | 5 | 5 | 12 | 22 | -10 | 8 |
| 18 | Crystal Palace | 11 | 1 | 4 | 6 | 8 | 15 | -7 | 7 |
| 19 | Wolverhampton WanderersWolves | 11 | 1 | 3 | 7 | 16 | 27 | -11 | 6 |
| 20 | Southampton | 11 | 1 | 1 | 9 | 7 | 21 | -14 | 4 |
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