Hearts have made two changes to the team that lost 4-1 against Motherwell on Saturday, with Dale Carrick and Jordan McGhee replacing Paul McCallum and Brad McKay.
Carrick returns to partner Lewis Stevenson up top, while McGhee slots in at right-back.
Kilmarnock, meanwhile, welcome David Moberg Karlsson, Sean Clohessy and Michael Gardyne into the team following their 2-0 loss to St Mirren last time out.
Hearts are currently bottom of the table, while Kilmarnock are eighth.
Hearts: MacDonald; McGhee, McGowan, Wilson, McHattie; Paterson, Hamill, Robinson, Nicholson; Stevenson, Carrick
Kilmarnock: Samson; Tesselaar, Boyd, Karlsson, Clohessy; McKenzie, Gardyne, O'hara, Slater; Pascali, Ashcroft
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