Juventus vs. Lazio (Saturday, 2.00pm)
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Having enjoyed a strong start to the Serie A season, Juventus return from the international break on Saturday afternoon, when Lazio arrive in Turin.
Unbeaten after three rounds, Juve's form has not been matched by their Roman counterparts, who began with back-to-back defeats before beating the Scudetto holders.
We say: Juventus 2-1 Lazio
Two of the best defensive teams in last season's Serie A meet on Saturday, but Lazio have proved more vulnerable at the back this term. While Juventus will win no prizes for flair, they can be ruthlessly efficient and are well-equipped on the counter, so the Old Lady may again get the better of visitors from the capital.
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Inter Milan vs. AC Milan (Saturday, 5.00pm)
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With their flawless records on the line, Italian heavyweights Inter Milan and AC Milan meet at San Siro on Saturday evening, when they scrap it out for top spot in Serie A.
Both have racked up three wins from three ahead of the first Derby della Madonnina of the season, so something must give when two giants of Calcio collide.
We say: Inter Milan 2-1 AC Milan
Inter and Milan not only top the table together but have also scored the most goals in Serie A this season, with eight apiece. However, Saturday's contest should be much tighter, with the fear of derby defeat proving a major factor.
As a result, scoring twice would surely be enough to secure maximum points, and such is the Nerazzurri's firepower they can do so and beat their Rossoneri rivals once again.
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Genoa vs. Napoli (Saturday, 7.45pm)
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Eight places separate Genoa and Napoli in the Serie A table heading into gameweek four's game at Stadio Luigi Ferraris on Saturday.
Alberto Gilardino's team have picked up three points from an available nine, with Rudi Garcia's side losing their 100% record to Lazio before the international break.
We say: Genoa 1-3 Napoli
Osimhen could be back among the goals for a Napoli side keen to get back to winning ways after losing to Lazio before the hiatus, leaving Genoa to wait for their first home win since returning to the league.
