After both sides kicked off their league campaigns on Saturday, Leyton Orient and Queens Park Rangers will square off in EFL Cup action on Wednesday, with a place in the second round on the line.
The two teams had identical starts to the league season, albeit two divisions apart, as Leyton Orient drew 1-1 with Salford City while their visitors were held to the same scoreline by Millwall in the Championship opener.
Match preview
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After a finishing 17th in the curtailed 2019-20 season, their first back in League Two after a brief drop into the fifth tier, Leyton Orient had a much better campaign last year, consolidating their place with a commendable 11th-placed finish.
As a result, the natural progression for this season would not only be to establish themselves in the top half, but also to aim for a playoff place, with three teams earning automatic promotion and sides down to seventh spot battling in the playoffs for a place in League One.
They faced a tough test in the opening game, travelling to take on Salford City, one of the favourites to win promotion, and Kenny Jackett's men came away with a creditable point.
Omar Beckles put them ahead on the half-hour mark, but Matty Willock drew the hosts level before half time and neither side were able to find a decisive goal.
Orient should certainly take the positives from an away point against a heavily-fancied side to start the campaign, and they have the chance to pick up another impressive result when they host Championship opposition in the form of Mark Warburton's QPR.
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The feeling around the Hoops heading into the Championship campaign is certainly somewhat similar to that of their opponents in League Two, with the hopes of an impressive season battling at the top end of the division.
In a much more sustainable model than the regime that saw them reach and drop out of the top flight twice last decade, the London outfit have taken huge strides towards a return to the Premier League, and after an impressive end to last season, finishing in ninth spot, they look in a strong position to push on and battle for a place in the top six this year.
Heading into the campaign with plenty of optimism, QPR began with a home clash against Millwall, but they did not get off to a good start as Jed Wallace put the Lions ahead inside the first 15 minutes.
Robert Dickie drew the Hoops level on the half-hour mark, but Warburton's men were unable to find a decisive goal, eventually settling for a point against resolute opposition.
Before they return to league action at the weekend, the Hoops will be keen to put a cup victory on the board to settle the mood and build confidence.
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Team News
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With only a short gap between Wednesday's cup game and the upcoming league outing on Saturday, Leyton Orient may choose to give rests to some of their crucial players, with 36-year-old midfielder Darren Pratley a likely candidate to be rotated with priority on a strong start to the league season.
Craig Clay should still lead the midfield as Jackett looks to find a balance between rotation and giving Orient the best chance of progressing.
The front line will again be led by Aaron Drinan, who joined in the summer transfer window from Ipswich Town.
Warburton will look to keep QPR in his favoured system of three at the back with a front two, although he could take the opportunity of a cup game against League Two opposition to take a look at his squad players.
Moses Odubajo should again be deployed on the right-hand side, while Norwich City loanee Sam McCallum could be handed his first start for the Hoops on the opposite flank.
Midfielder Sam Field is ruled out through injury, meaning Andre Dozzell will likely start alongside Faysal Bettache in the engine room.
Experienced attacker Albert Adomah could also feature from the start as part of heavy rotation, allowing a rest for Charlie Austin in preparation for Saturday's Championship clash with Hull City.
Leyton Orient possible starting lineup:
Vigouroux; James, Beckles, Happe, Wood; Clay, Young, Kyprianou; Kemp, Drinan, Smith
Queens Park Rangers possible starting lineup:
Archer; Kakay, Dickie, Dunne; Odubajo, Dozzell, Bettache, McCallum; Willock; Dykes, Adomah
We say: Leyton Orient 0-2 Queens Park Rangers
Mark Warburton could give chances to players outside of his strongest XI as he looks to gain a greater understanding of his squad, but we still see a rotated QPR side having far too much for Leyton Orient.
The former Brentford and Rangers manager has brought about a set system with the Hoops, and that impressive structure should see them over the line and through to the second round with squad players keen to impress.
Top tip
Data Analysis
Our analysis of all available data, including recent performances and player stats up until an hour before kickoff, suggested the most likely outcome of this match was a Queens Park Rangers win with a probability of 55.42%. A draw had a probability of 23.1% and a win for Leyton Orient had a probability of 21.51%.
The most likely scoreline for a Queens Park Rangers win was 0-1 with a probability of 10.58%. The next most likely scorelines for that outcome were 1-2 (9.85%) and 0-2 (9.54%). The likeliest drawn scoreline was 1-1 (10.92%), while for a Leyton Orient win it was 1-0 (6.06%).