Portuguese outfit Porto will travel to Malaga on Wednesday night with a slender 1-0 advantage from the opening leg.
Joao Moutinho scored the only goal of that game, but the Dragees missed a host of other goalscoring chances which their Spanish opposition will look to take advantage of this time around.
Prior to the defeat in Portugal, Malaga had not lost any of their eight matches in the Champions League this season. They have also won three of four encounters in front of their own supporters.
The Spaniards may also be able to call upon the services of former Arsenal attacker Julio Baptista, who has recently returned to training following a brief stint on the sidelines with a hamstring strain.
Visiting Porto will also be boosted by the availability of Eliaquim Mangala after the French defender recovered from a muscular complaint.
Porto have travelled to Spain on 18 occasions, winning five times and losing 11.
Recent form
Malaga: DWWLDD
Porto: DWWWDW
Possible starting lineups:
Malaga: Caballero; Sanchez, Weligton, Demichelis, Antunes; Toulalan, Iturra, Baptista; Joaquin, Isco; Santa Cruz
Porto: Helton; Sandro, Mangala, Otamendi, Danilo; Gonzalez, Fernando, Moutinho, Varela; Martinez, Izmailov
Sports Mole says: 3-1
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