Manchester United boss Jose Mourinho has left Paul Pogba on the bench for the club's Champions League clash away at Sevilla this evening.
United will instead feature youngster Scott McTominay, who will play alongside both Ander Herrera and Nemanja Matic in a midfield three.
The visitors are also to feature a forward line made up of Romelu Lukaku, Alexis Sanchez and Juan Mata.
Sevilla have been able to recall Ever Banega just a week after being out injured with hamstring trouble, and he will partner Steven Nzonzi in midfield.
The hosts are to feature Muriel alone in attack with further support provided by Joaquin Correa, Franco Vazquez and Pablo Sarabia.
Sevilla: Sergio Rico; Jesús Navas, Mercado, Lenglet, Escudero; Banega, N'Zonzi; Sarabia, Vazquez, Correa; Muriel
Subs: Carrico, Mesa, Ben Yedder, Soria, Pizarro, Sandro, Nolito
Manchester United: De Gea; Valencia, Lindelof, Smalling, Young; Herrera, Matic, McTominay; Mata, Lukaku, Sanchez
Subs: Romero, Bailly, Darmian, Pogba, Rashford, Martial, Lingard