Premier League giants Arsenal and Manchester United will square off in the FA Cup third round.
Later this week, the Gunners and Red Devils will meet in an exact replica of the tie that will take place at the Emirates Stadium between January 9 and January 13.
Monday's draw has ensured that United will be making two visits to North London to meet Mikel Arteta's side as they bid to defend the trophy that they lifted in May.
Meanwhile, National League outfit Tamworth have been provided with a blockbuster tie of their own in the form of Tottenham Hotspur.
Manchester City will go up against Salford City, partly-owned by several Manchester United legends, while Premier League leaders Liverpool will welcome Accrington Stanley to Anfield.
Morecambe will make the trip to Stamford Bridge to face Chelsea, and Harrogate Town have been handed a Yorkshire derby at Leeds United.
Newcastle United play host to another League Two side in the form of Bromley, with the second and final all-Premier League tie being Aston Villa's clash with West Ham United.
FA Cup third-round draw in full
Southampton vs. Swansea City
Arsenal vs. Manchester United
Exeter City vs. Oxford United
Leyton Orient vs. Derby County
Reading vs. Burnley
Aston Villa vs. West Ham United
Norwich City vs. Brighton & Hove Albion
Manchester City vs. Salford City
Millwall vs. Dagenham & Redbridge
Liverpool vs. Accrington Stanley
Bristol City vs. Wolverhampton Wanderers
Preston North End vs. Charlton Athletic
Chelsea vs. Morecambe
Middlesbrough vs. Blackburn Rovers
Bournemouth vs. West Bromwich Albion
Mansfield Town vs. Wigan Athletic
Tamworth vs. Tottenham Hotspur
Hull City vs. Doncaster Rovers
Sunderland vs. Stoke City
Leicester City vs. Queens Park Rangers
Brentford vs. Plymouth Argyle
Coventry City vs. Sheffield Wednesday
Newcastle United vs. Bromley
Everton vs. Peterborough United
Wycombe Wanderers vs. Portsmouth
Birmingham City vs. Lincoln City
Leeds United vs. Harrogate Town
Nottingham Forest vs. Luton Town
Sheffield United vs. Cardiff City
Ipswich Town vs. Bristol Rovers
Fulham vs. Watford
Crystal Palace vs. Stockport County
