Manchester United have been drawn at home to Aston Villa in the FA Cup third round draw, while Chelsea face non-league opposition in the form of Chesterfield.
Despite the annual anticipation ahead of the last 64 of this competition, there were few stand out ties, with Steven Gerrard taking his Villa side to Old Trafford arguably the pick of them.
Last season's runners-up Chelsea will play host to National League club Chesterfield, while Premier League leaders Manchester City travel to Swindon Town.
Liverpool will start their campaign with a meeting against Shrewsbury Town, with defending champions Leicester City going up against Watford.
West Ham United go up against Leeds United at the London Stadium, and Arsenal have been handed a trip to Championship side Nottingham Forest.
Of the other non-league teams, Yeovil Town and Kidderminster Harriers meet Bournemouth and Reading respectively, while either Boreham Wood or St Albans City will square off against AFC Wimbledon.
Draw in full
Boreham Wood or St Albans v AFC Wimbledon
Yeovil Town v Bournemouth
Stoke City v Leyton Orient
Swansea City v Southampton
Chelsea v Chesterfield
Liverpool v Shrewsbury Town
Cardiff v Preston North End
Coventry City v Derby County
Burnley v Huddersfield
West Bromwich Albion v Brighton and Hove Albion
Kidderminster Harriers v Reading
Leicester City v Watford
Mansfield Town v Middlesbrough
Hartlepool United v Blackpool
Hull City v Everton
Bristol City v Fulham
Tottenham Hotspur v Morecambe
Millwall v Crystal Palace
Port Vale v Brentford
Swindon Town v Manchester City
Wigan Athletic v Blackburn Rovers
Luton Town v Harrogate Town
Birmingham City v Plymouth Argyle
Manchester United v Aston Villa
Wolverhampton Wanderers v Sheffield United
Newcastle United v Cambridge United
Barnsley v Ipswich Town or Barrow
Peterborough United v Bristol Rovers
West Ham United v Leeds United
Queens Park Rangers v Rotherham
Charlton Athletic v Norwich City
Nottingham Forest v Arsenal