Premier League leaders Manchester City will be looking to extend their record winning run across all competitions to 16 games when they welcome an out-of-sorts Tottenham Hotspur side to the Etihad Stadium in gameweek 24.
The week begins in style too as third-placed Leicester City host fourth-placed Liverpool, with the champions looking to bounce back from defeat to Man City last time out.
Manchester United take on relegation-threatened West Bromwich Albion, while Arsenal host Leeds United and Chelsea will look to maintain their unbeaten start under Thomas Tuchel at home to Newcastle United on Monday night.
Click play below to watch or listen to Sports Mole Editor Barney Corkhill and Football Editor Matt Law discuss their predictions for gameweek 24, in addition to Wednesday's two games in hand.
Watch the full discussion here:
Or you can listen to the full podcast here:
SATURDAY
12.30pm - Leicester vs. Liverpool (0:17)
3pm - Crystal Palace vs. Burnley (7:50)
5.30pm - Manchester City vs. Tottenham (13:08)
8pm - Brighton & Hove Albion vs. Aston Villa (19:00)
SUNDAY
12pm - Southampton vs. Wolverhampton Wanderers (23:37)
2pm - West Bromwich Albion vs. Manchester United (28:47)
4.30pm - Arsenal vs. Leeds United (36:08)
7pm - Everton vs. Fulham (39:59)
MONDAY
6pm - West Ham United vs. Sheffield United (44:18)
8pm - Chelsea vs. Newcastle United (48:06)
WEDNESDAY
6pm - Burnley vs. Fulham (52:38)
8.15pm - Everton vs. Man City (56:22)