Manchester United's 4-0 loss at Liverpool in the Premier League on Tuesday evening make it 9-0 on aggregate to the Merseyside giants during the 2021-22 campaign.
Jurgen Klopp's side ran out 5-0 winners over the Red Devils at Old Trafford back in October, and the title hopefuls were similarly dominant in their home match against their bitter rivals on Tuesday.
The 9-0 aggregate defeat to Liverpool represents their worst record in a season versus a team since 1892-93, when they suffered an 11-0 loss over two matches to Sunderland.
The Black Cats beat Man United, then Newton Heath, 5-0 away from home before recording a 6-0 victory in the reverse fixture one month later.
Luis Diaz and Sadio Mane were both on the scoresheet at Anfield, while Mohamed Salah netted a brace, as the Red Devils saw their top-four hopes take a huge hit.
Ralf Rangnick's side are currently sixth in the table, three points behind fourth-placed Tottenham Hotspur, who have a game in hand.
Man United will take on Arsenal (A), Chelsea (H), Brentford (H), Brighton & Hove Albion (A) and Crystal Palace (A) in their final five league matches of the season.
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