Chelsea manager Jose Mourinho has now gone 76 Premier League matches without defeat at Stamford Bridge.
What's more, the Portuguese coach remains unbeaten from his encounters with Arsene Wenger, winning six and drawing five.
Staying with Wenger, who took charge of Arsenal for the 1000th time, this was his joint-heaviest defeat in terms of margin since he arrived in England in 1996.
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Cardiff City 3-6 Liverpool
The hat-trick that Luis Suarez scored took his goals tally to 28 from 25 appearances.
Also among the goals was Martin Skrtel, who has now scored six this season, making him the joint-leading goalscoring defender along with Seamus Coleman.
Meanwhile, the Bluebirds have won just five of their 16 matches at the Cardiff City Stadium.
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Everton 3-2 Swansea City
Leighton Baines has taken 12 Premier League penalties for Everton and scored all of them.
The left-back's goal helped the Toffees in their way to victory, having lost just one of their last 24 fixtures at Goodison Park and winning 18 of them.
As for the visiting Swans, they have managed to win just two of their previous 16 outings.
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Hull City 2-0 West Bromwich Albion
West Brom had not lost any of the previous seven meetings between the two clubs prior to this clash at the KC Stadium.
Among the goals for Hull was Liam Rosenior, who found the net for the first time since 2009.
Shane Long also scored on what was his first appearance against the Baggies since he left them for Hull in January.
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Manchester City 5-0 Fulham
Yaya Toure's hat-trick was the eighth that has been scored in the Premier League this season.
Both of the penalties that he scored were conceded by Fulham defender Fernando Amorebieta, who became the first player to give away two penalties in one match since 2010.
Basement side Fulham have now let in 70 goals from 31 matches.
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Newcastle United 1-0 Crystal Palace
Five of Papiss Cisse's last 11 goals for Newcastle have been scored in the 90th minute or later.
This latest defeat means that Palace have lost 11 of their 15 away matches, scoring 11 goals in the process.
Tony Pulis's team attempted just one shot on target at St James' Park.
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Norwich City 2-0 Sunderland
Alexander Tettey's volley from distance was his first ever goal in the Premier League in what was his 43rd outing for the Canaries.
Norwich have now gone six home matches without defeat, winning three of those.
As for Sunderland, Marcos Alonso became the seventh Sunderland player to be sent off this season.
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West Ham United 0-2 Manchester United
Wayne Rooney's brace of goals took his tally for United to 212 - making him the club's third highest goalscorer of all time.
It also meant that he has scored 10 Premier League goals against the Hammers.
Staying with West Ham, they have lost three consecutive games for the first time under Sam Allardyce's management.
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Tottenham Hotspur 3-2 Southampton
Having trailed 2-0, Spurs claimed points for the first time from a losing position at home this season.
Their match-winner, Gylfi Sigurdsson, scored his first goal in the Premier League since September.
The last five meetings between these clubs have ended with one-goal winning margins.
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Aston Villa 1-4 Stoke City
All four of Stoke's goals involved Peter Crouch, who scored two and assisted the others.
Also, the Potters had just five shots on target over the course of the 90 minutes.
Villa's poor form at home continued, with Paul Lambert's side now having lost nine of their 16 matches at Villa Park.
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