Sir Alex Ferguson has handed Tom Cleverley a starting place in midfield against Athletic Bilbao this evening, with Wayne Rooney acting as a lone striker for Manchester United.
The Red Devils travelled to Spain for the second leg of the Europa League clash without Phil Jones, Anderson and Nani.
While Antonio Valencia was included in the 20-man squad, the winger has failed to make the bench for the fixture following four months out through injury.
United young gun Paul Pogba, who has reportedly decided to stay put at Old Trafford, has been named a substitute for the match.
The English champions need to overturn a 3-2 defeat in order to qualify for the next round.
Athletic: Iraizoz; Aurtenetxe, Amorebieta, Iraola, Iturraspe; De Marcos, Herrera, Javi Martínez, Llorente; Susaeta, Muniain
Subs: Raúl, San José, Ekiza, Íñigo Pérez, Toquero, David López, Ibai Gómez.
Man United: De Gea; Evra, Ferdinand, Evans, Rafael; Cleverley, Carrick; Giggs, Park Ji-Sung, Young; Rooney
Subs: Amos, Smalling, Fabio, Scholes, Pogba, Hernández, Welbeck.