Javier Hernandez will start his first Premier League game this season when Manchester United visit Bolton Wanderers.
The Mexican international, who missed the start of the season because of concussion, replaces the injured Danny Welbeck up front.
Wayne Rooney will partner Hernandez while at the back Rio Ferdinand returns for the Red Devils.
Phil Jones moves to right-back with Chris Smalling dropping to the bench.
For Wanderers Dedryck Boyata and Mark Davies make their first league starts of the season with Davies deposing Muamba in the heart of midfield.
Manchester United: De Gea; Evra, Jones, Ferdinand, Evans; Anderson, Cleverley, Nani, Young; Hernandez, Rooney
Bolton Wanderers: Jaaskelainen; Boyata, Cahill, Knight, Robinson; Eagles, Mark Davies, Reo-Coker, Petrov; Klasnic, Kevin Davies
