Napoli coach Rafael Benitez has made five changes to his side that beat AC Milan 2-1 at the weekend, with Gonzalo Higuain keeping his place in attack.
Lorenzo Insigne, Valon Behrami, Jose Maria Callejon, Raul Albiol and Miguel Britos all drop to the bench, with Federico Fernandez, Blerim Dzemaili, Pablo Armero, Goran Pandev and Dries Mertens all starting.
For Sassuolo Domenico Berardi returns from his ban to start in attack.
Napoli: Reina; Mesto, Cannavaro, Fernandez, Armero; Inler, Dzemaili; Pandev, Hamsik, Mertens; Higuain
Sassuolo: Pegolo; Antei, Acerbi, Bianco, Longhi; Kurtic, Magnanelli, Laribi; Schelotto, Zaza, Berardi
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