Northampton Town make two changes to the side that lost to York City last time out, with James Hurst and Joe Widdowson coming in for Ishmel Demontagnac and Kevin Amankwaah.
Chesterfield, meanwhile, make four changes, with Tendayi Darikwa, Ritchie Humphreys, Dan Gardner and Eoin Doyle all coming into the side.
Chesterfield are fourth in the league and are looking to push for promotion, while Northampton are rock bottom.
Northampton Town: Duke; Hurst, Collins, McGinty, Widdowson; Deegan, Tozer, Carter, Blair; Hope, German
Chesterfield: Lee; Evatt, Cooper, Humphreys, Darikwa; Ryan, Morsy, Gardner, Banks; Roberts, Doyle
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