A late equaliser from CSKA Moscow's Pontus Wernbloom has left this tie in the balance heading into the return leg at the Bernabeu.
Hosting Real Madrid will be without their left-sided duo Fabio Coentrao and Angel Di Maria.
However, Karim Benzema is expected to be passed fit and is likely to start in place of Argentine striker Gonzalo Higuain.
Visiting CSKA are able to call upon Pavel Mamaev and Kirill Nababkin, both of whom missed the match in Russia because of suspension.
CSKA Moscow has lost just one of their last 12 away matches in all competitions, winning three and drawing eight.
Current form:
Real Madrid: WWDWWW
CSKA Moscow: LWDDDW
Possible lineups:
Real Madrid: Casillas; Arbeloa, Pepe, Ramos, Marcelo; Khedira, Alonso; Ozil, Kaka, Ronaldo; Benzema
CSKA Moscow: Chepchugov; A Berezutski, V Berezutski, Ignashevich; Schennikov, Wernbloom, Mamaev; Dzagoev, Honda, Musa; Doumbia
Sports Mole says: 2-0