Tachira vs. Internacional (Tuesday, 11.15pm)
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Deportivo Tachira have an opportunity to move into first place in Group B of the Copa Libertadores on Tuesday when they host Internacional at Estadio Polideportivo de Pueblo Nuevo.
The Venezuelans are hoping for a bit of payback against Colorado, who beat them 4-0 in Brazil in their second match of the group stage.
We say: Deportivo Tachira 2-4 Internacional
Losing their first match of this competition appears to have lit a fire under Internacional, who have looked almost unstoppable since then, winning four of their last five games in all competitions, scoring 19 times while conceding only three.
Deportivo have not lost this season at home, but their opponents have too many weapons who can beat you, and the Venezuelans could have their hands full trying to keep up.
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The Strongest vs. Barcelona (Tuesday, 11.15pm)
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Barcelona SC square off against The Strongest on Tuesday with the opportunity to confirm their place in the last 16 of the Copa Libertadores.
While the visitors have a 100% record and three successive clean sheets, The Strongest have lost every game in Group C without scoring a goal.
We say: The Strongest 0-2 Barcelona SC
Given the respective records of the two sides, we can only predict a routine victory for the visitors. Complacency could be an issue, but Barcelona should have plenty in the tank to ease to another three points.
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Santos vs. Boca Juniors (Tuesday, 11.15pm)
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Boca Juniors meet Santos on Tuesday evening looking to move to the brink of the Copa Libertadores last 16.
However, while the visitors can move six points ahead of their next opponents, Santos will move back into the mix with victory at the Urbano Caldeira Stadium.
We say: Santos 1-1 Boca Juniors
Having prevailed in the reverse fixture, Boca do not necessarily have to push for maximum points from this game. With that in mind, we are backing a competitive draw between two of South America's top sides, a result which will only favour the visitors.
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Cristal vs. Racing (Wednesday, 1.30am)
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Racing Club face Sporting Cristal on Tuesday evening knowing that victory could put them on the brink of qualifying for the Copa Libertadores last 16.
While the home side have failed to win any of their opening three games in Group E, the Peruvian side know that maximum points will put them back into the mix.
We say: Sporting Cristal 1-2 Racing Club
While a lack of goals have been a problem for Cristal, they have an opportunity to put things right on Tuesday. However, the visitors are proving difficult to beat on this stage, and we expect a hard-fought win for the Argentine side.
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Union La Calera vs. Flamengo (Wednesday, 1.30am)
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Union La Calera will try to get back in the race for qualification into the knockout stage of the Copa Libertadores when they host Flamengo in Group G action on Tuesday.
The Chilean side have one point from their opening three matches, while the 2019 winners of this event are already guaranteed a spot in the next round of the competition.
We say: Union La Calera 1-3 Flamengo
Union are missing two critical pieces of their midfield, which should give the Brazilians plenty of time and space to counter, leaving the Chilean side vulnerable to the quick and dynamic Flamengo attack.
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Independiente vs. Palmeiras (Wednesday, 1.30am)
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Independiente del Valle will hope to get a little retribution on Tuesday when they host Palmeiras, who destroyed them on matchday two of their Copa Libertadores campaign 5-0.
The Ecuadorians got right back in the race for a spot in the knockout stage of this tournament by shutting out Universitario 4-0, while the defending champions remain perfect, winning all three of their games thus far.
We say: Independiente del Valle 1-3 Palmeiras
The Brazilians know what it takes to go far in this competition, and they have the tools to win it all once again.
Independiente del Valle should keep the score respectable, given they are playing at home, where they thrive, but they will have a hard time matching the speed and aggression that Palmeiras possess.