Eric Dier will perform as a centre-back this evening in Tottenham Hotspur's Champions League group game against Bayer Leverkusen in Germany.
The England international, who usually plays as a defensive midfielder, has dropped into the role as a result of Toby Alderweireld's injury.
Elsewhere on the pitch, Kieran Trippier and Danny Rose have replaced full-backs Kyle Walker and Ben Davies respectively, while Moussa Sissoko has fallen to the substitutes' bench.
Heung-min Son comes into the fold to provide support to striker Vincent Janssen, while Victor Wanyama, Dele Alli, Erik Lamela and Christian Eriksen keep their places following last weekend's 1-1 draw with West Bromwich Albion.
Meanwhile, Leverkusen captain Lars Bender has returned to the starting XI after missing Saturday's 2-1 defeat to Werder Bremen with the flu, and Javier Hernandez will lead the line.
Bayer Leverkusen: Leno; Bender, Tah, Toprak, Henrichs; Kampl, Aranguiz, Mehmedi, Calhanoglu; Hernandez, Kiessling
Tottenham Hotspur: Lloris; Trippier, Dier, Vertonghen, Rose; Wanyama, Alli; Lamela, Eriksen, Son; Janssen
Subs: Vorm, Carter-Vickers, Davies, Dembele, Onomah, Sissoko, Winks
Follow Sports Mole's live text commentary of the game here.
Danielle Joynson
