Santos president Luis Alvaro Ribeiro has revealed that the club would consider offers for Ganso this summer.
The Brazilian club had previously stated that they had no interest in allowing the 22-year-old to leave.
However, Ribeiro has admitted that the club have now changed their stance by insisting that only striker Neymar is not for sale at any price.
"Only Neymar is not negotiable," Ribeiro told Portuguese newspaper Record. "All other players, including Ganso, have the door open, depending on the proposals as they arise.
"If the will of Ganso is to leave, and there are clubs interested, then we are willing to listen to offers for him."
Midfielder Ganso recently rejected a new contract offer from the club.