Empoli vs. Lecce (Saturday, 2.00pm)
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After going winless in their last four outings, Empoli will fancy their chances of snapping that streak when they host Lecce at Stadio Carlo Castellani for round 20 of Serie A.
The Azzurri currently sit 12th in the standings with 20 points from 19 matches, holding a three-point cushion over the visitors, who remain rooted in the drop zone, only propped up by Venezia and Monza in 19th and 20th, respectively.
We say: Empoli 2-1 Lecce
Neither side carries much momentum into this encounter, with Empoli struggling at home and Lecce enduring similar difficulties on their travels.
Given the lack of form from both sides, a closely contested match is expected, though Empoli are more likely to have the edge, having won three of the last five meetings between the sides at the Castellani.
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Udinese vs. Atalanta (Saturday, 2.00pm)
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Having been unseated as Serie A leaders before losing in the Super Cup semi-finals, Atalanta BC aim to reclaim first place by beating Udinese on Saturday afternoon.
La Dea trail leaders Napoli by three points but with one game in hand, while the Bianconeri are still outside contenders for Europe.
We say: Udinese 1-2 Atalanta BC
As Udinese are missing their focal point up front - and they have been a little leaky at the back - Atalanta should return to winning ways.
The hosts have conceded nine goals across their last four home fixtures, so they may struggle to keep La Dea at arm's length.
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Torino vs. Juventus (Saturday, 5.00pm)
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Aiming to continue their long dominance of the Turin derby, Italian giants Juventus will visit city rivals Torino on Saturday evening.
Ahead of the 183rd clash between them since 1929, Juve are unbeaten in Serie A this season - and in 21 games against Toro.
We say: Torino 0-1 Juventus
Derby dominators Juventus can surely keep another clean sheet against Torino's ailing attack, so it could be a matter of making the breakthrough and then sitting tight to collect maximum points.
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AC Milan vs. Cagliari (Saturday, 7.45pm)
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Fresh from their dramatic Super Cup triumph, AC Milan will host Cagliari in Serie A's Saturday night kickoff, aiming to continue a superb start to Sergio Conceicao's reign.
The Rossoneri twice recovered from trailing at half time to win two tough matches and lift the Supercoppa Italiana, while their Sardinian counterparts celebrated a more modest success last time out.
We say: AC Milan 3-0 Cagliari
Fired up by a fresh face in the dugout, Milan are well set to continue their dominance of this week's visitors - albeit they remain far from flawless.
Nearly half the 32 league goals Cagliari have conceded this term followed set pieces - a league high of 14 - so the hosts will surely pay particular attention to that glaring weakness.