Lorient FC captain Fabien Audard returns to the Ligue 1 side, replacing Benjamin Lecomte in goal.
Mathias Autret features in the Lorient midfield, while Maxime Barthelme partners Kevin Monnet-Paquet up front.
Valenciennes also welcome back their captain David Ducourtioux, who missed the side's 1-1 draw with Marseille last weekend. He replaces Schmitz Rafael in defence.
The only other change sees midfielder Pape Abdou Camara sacrificed for Nicolas Isimat-Mirin, who starts in defence.
Valenciennes FC: Nicolas Penneteau; David Ducourtioux (c), Gil, Nicolas Isimat-Mirin, Gaetan Bong; Rudy Mater, Carlos Sanchez Moreno, Gael Danic, Renaud Cohade; Vincent Aboubakar, Foued Kadir
Lorient FC: Fabien Audard (c); Lamine Kone, Alaixys Romao, Bruno Ecuele Manga, Lucas Mareque, Lamine Gassama; Arnold Mvuemba, Mathias Autret, Innocent Emeghara; Maxime Barthelme, Kevin Monnet-Paquet