The Football Association of Wales has announced that the Dragons will take on 2018 World Cup qualifiers Panama in an international friendly next month.
This will be the first meeting between the two sides, following Panama's qualification for their first major tournament.
The fixture will take place on Tuesday, November 14 at Cardiff City Stadium, four days after Wales's friendly against France in Paris.
Panama qualified for the World Cup by beating Costa Rica 2-1 in their final qualifying match, with Roman Torres scoring the winner, and currently sit 49th in FIFA's World Rankings.
Wales, meanwhile, will not be heading to Russia next summer after missing out on a playoff spot in their final qualifier against the Republic of Ireland, who claimed a 1-0 win in Cardiff.