Jim Bolger has been forced to retire Parish Hall from this afternoon's Abu Dhabi Irish 2000 Guineas due to a leg infection.
The colt, who won the Dewhurst last season, was favourite for this afternoon's race at Curragh.
Trainer Bolger confirmed the news to Press Association Sport, saying: "It's not a very pleasant experience getting so close to the race.
"He's picked up a leg infection but at this stage I've no idea how long it will keep him off for.
"I'd imagine I will have a better idea by Wednesday or Thursday."
Bolger added that Parish Hall will also miss next weekend's Epsom Derby.
