Saturday's Betfred Super League match between Catalans and Wigan has been postponed after three Dragons players and a member of their non-playing staff returned positive coronavirus tests.
The entire Dragons squad will now isolate ahead of further tests later this week.
Two of the players who have the virus were in the side against Wakefield last weekend and as a result of the test and trace analysis, two of Trinity's squad also have to self-isolate.
A Super League statement read: "Catalans Dragons' Betfred Super League fixture against Wigan Warriors, which had been scheduled for this Saturday (August 29), has been postponed, after three Dragons players and a member of their non-playing staff returned positive tests in routine Covid-19 testing today (Tuesday).
"Wigan Warriors will now play Castleford Tigers, in a fixture which had been due in Round 18. Castleford had been due to have a bye this weekend, but all clubs with a bye have been instructed to be on stand-by to step up in such an eventuality, given the exceptional current circumstances.
"The Dragons squad were all instructed to isolate as soon as the news of the positive tests was received, prompting the postponement of the Wigan fixture. They will have further tests later this week.
"Of the players who have tested positive, two played in Saturday's Coral Challenge Cup tie against Wakefield Trinity. Test and trace analysis has shown that two of the Wakefield players will also be required to self-isolate – but at this stage their fixture against Warrington Wolves is expected to go ahead as scheduled on Sunday."