England head coach Eddie Jones has named seven uncapped players in his 37-man training squad for the upcoming autumn internationals.
Wasps flanker Sam Jones and his teammate Nathan Hughes are among the debutants, while Mike Williams and Harlequins' 20-year-old centre Joe Marchant have also received call-ups.
Josh Beaumont, Ben Te'o and Dan Robson make up the uncapped seven, who will head to Brighton for a three-day training camp with the rest of the squad.
The final squad for internationals against South Africa, Fiji, Argentina and Australia will be announced on October 26.
"The Old Mutual Wealth Series will be a big challenge and the players will need to step up to the mark," said Jones. "With a number of players missing through injury it's a good opportunity for others to put their hands up and show us what they're made of.
"I think it's a good situation to be in. Injuries allow us to strengthen the depth of our squad and develop robustness. Ideally, by the Rugby World Cup in 2019, we're looking to have three players in every position who are interchangeable.
"At the moment we have seven of our most influential players not playing regularly for their clubs, but that should be no excuse. England have not beaten South Africa since 2006 and this needs to change."
Jones has also named his 45-man elite player squad.
England 45-man squad:
Forwards: Josh Beaumont (Sale Sharks), Jack Clifford (Harlequins), Dan Cole (Leicester Tigers), Luke Cowan-Dickie (Exeter Chiefs), Will Evans (Leicester Tigers), Charlie Ewels (Bath Rugby), Ellis Genge (Leicester Tigers), Jamie George (Saracens), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Nathan Hughes (Wasps), Maro Itoje (Saracens), Sam Jones (Wasps), George Kruis (Saracens), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Matt Mullan (Wasps), Chris Robshaw (Harlequins), Kyle Sinckler (Harlequins), Tommy Taylor (Wasps), Billy Vunipola (Saracens), Mako Vunipola (Saracens), Mike Williams (Leicester Tigers)
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens), George Ford (Bath Rugby), Alex Goode (Saracens), Mike Haley (Sale Sharks), Jonathan Joseph (Bath Rugby), Alex Lozowski (Saracens), Joe Marchant (Harlequins), Jonny May (Gloucester Rugby), Jack Nowell (Exeter Chiefs), Dan Robson (Wasps), Semesa Rokoduguni (Bath Rugby), Henry Slade (Exeter Chiefs), Ben Spencer (Saracens), Ben Te'o (Worcester Warriors), Manu Tuilagi (Leicester Tigers), Anthony Watson (Bath Rugby), Ben Youngs (Leicester Tigers)
England 37-man training squad:
Forwards: Josh Beaumont (Sale Sharks), Dan Cole (Leicester Tigers), Jamie George (Saracens), Teimana Harrison (Northampton Saints) *injury replacement for James Haskell (Wasps), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Nathan Hughes (Wasps), Maro Itoje (Saracens), Sam Jones (Wasps), George Kruis (Saracens), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Ben Morgan (Gloucester Rugby) *injury replacement for Jack Clifford (Harlequins), Chris Robshaw (Harlequins), Tommy Taylor (Wasps), Billy Vunipola (Saracens), Mako Vunipola (Saracens), Mike Williams (Leicester Tigers)
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Ollie Devoto (Exeter Rugby) *injury replacement for Manu Tuilagi (Leicester Tigers), Owen Farrell (Saracens), George Ford (Bath Rugby), Alex Goode (Saracens), Jonathan Joseph (Bath Rugby), Joe Marchant (Harlequins), Jack Nowell (Exeter Chiefs), Dan Robson (Wasps), Semesa Rokoduguni (Bath Rugby), Henry Slade (Exeter Chiefs), Ben Te'o (Worcester Warriors), Anthony Watson (Bath Rugby), Marland Yarde (Harlequins) *injury replacement for Jonny May (Gloucester Rugby), Ben Youngs (Leicester Tigers)
