Leaders Harlequins will travel to bottom-placed Sale Sharks in the Aviva Premiership on Friday looking to avoid an upset at the Salford City Stadium.
Conor O'Shea's side regained top spot in the table last weekend with a narrow 25-21 win over Leicester Tigers - their 11th triumph out of 12 in all competitions.
However, two consecutive victories for Sale have seen the strugglers move to within a point of safety.
Rob Miller, Fraser McKenzie, Tommy Taylor and Ross Harrison all come into the Sharks' starting XV.
Karl Dickson and Nick Easter return for the visitors, who are without England internationals Danny Care, Mike Brown, Joe Marler and Chris Robshaw.
Recent form
Sale: LLWWWW
Quins: WWWWLW
Lineups
Sale: Miller, Amesbury, Leota, Tuitupou, Cueto, Cipriani, Cliff, Gaskell, Seymour, Braid, Myall, McKenzie, Thomas, Taylor, Harrison
Replacements: Jones, Lewis-Roberts, Buckley, Holmes, Vernon, Willis, Macleod, Addison
Quins: Chisholm, Williams, Hopper, Turner-Hall, Monye, Botica, Dickson, Easter, Wallace, Fa'asavalu, Robson, Matthews, Johnston, Gray, Lambert
Replacements: Buchanan, Marfo, Collier, Twomey, Trayfoot, Burns, Clegg, Lowe
Sports Mole: Quins to get the win
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