Wales have selected two uncapped players James Davies and Josh Adams in the squad for the upcoming Six Nations tournament.
The 39-man setup, led by captain Alun Wyn Jones, also includes Dillon Lewis, who made his debut for Wales in the summer tour last year.
Notable absentees include Jamie Roberts and Kristian Dacey, while Dan Evans and Gethin Jenkins have also failed to make the cut this time around.
Wales head coach Warren Gatland said: "It is an exciting opportunity for the two new caps. James' form over the last couple of years has been impressive, he's in a competitive area but we look forward to seeing what he can do. For Josh it's a great opportunity, he's been on great form and the back-three is somewhere we are looking to create depth in.
"We have selected a larger squad and it is an opportunity for us to work with a wider group and continue building for the next 18 months. It's important to have a group of players who are used to the environment, know what is expected and are familiar with things and that will really benefit us going forward."
Wales will face Scotland at the Principality Stadium in Cardiff for their opening clash on February 3.
Wales Six Nations squad in full:
Forwards (21):
Rob Evans (Scarlets) (20 Caps)
Wyn Jones (Scarlets (5 Caps)
Nicky Smith (Ospreys) (16 Caps)
Scott Baldwin (Ospreys) (34 Caps)
Elliot Dee (Dragons) (2 Caps)
Ken Owens (Scarlets) (52 Caps)
Tomas Francis (Exeter Chiefs) (26 Caps)
Samson Lee (Scarlets) (34 Caps)
Dillon Lewis (Cardiff Blues) (2 Caps)
Adam Beard (Ospreys) (2 Caps)
Bradley Davies (Ospreys) (57 Caps)
Seb Davies (Cardiff Blues) (3 Caps)
Cory Hill (Dragons) (10 Caps)
Alun Wyn Jones (Ospreys) (113 Caps) (CAPT)
James Davies (Scarlets) (*Uncapped)
Taulupe Faletau (Bath) (70 Caps)
Ellis Jenkins (Cardiff Blues) (5 Caps)
Ross Moriarty (Gloucester) (17 Caps)
Josh Navidi (Cardiff Blues) (7 Caps)
Aaron Shingler (Scarlets) (13 Caps)
Justin Tipuric (Ospreys) (52 Caps)
Backs (18):
Aled Davies (Scarlets) (5 Caps)
Gareth Davies (Scarlets) (27 Caps)
Rhys Webb (Ospreys) (31 Caps)
Gareth Anscombe (Cardiff Blues) (11 Caps)
Dan Biggar (Ospreys) (60 Caps)
Rhys Patchell (Scarlets) (5 Caps)
Rhys Priestland (Bath) (50 Caps)
Hadleigh Parkes (Scarlets) (1 Cap)
Owen Watkin (Ospreys) (2 Caps)
Owen Williams (Gloucester) (3 Caps)
Scott Williams (Scarlets) (51 Caps)
Josh Adams (Worcester Warriors) (*Uncapped)
Hallam Amos (Dragons) (15 Caps)
Alex Cuthbert (Cardiff Blues) (47 Caps)
Steff Evans (Scarlets) (5 Caps)
Leigh Halfpenny (Scarlets) (74 Caps)
George North (Northampton Saints) (69 Caps)
Liam Williams (Saracens) (45 Caps)
