Jamie Murray and John Peers will end their doubles partnership following the ATP World Tour Finals in London in November.
The pair reached the finals of Wimbledon and the US Open and won ATP titles in Brisbane and Hamburg this year.
They have been the fourth most successful doubles partnership in the world this season, which will finish as a career-best for both players.
The Scot will link up with Brazil's Bruno Soares for the 2016 season, who has won 11 ATP titles with his current partner Alexander Peya.
