Goalkeeper Fraser Forster has returned to the Southampton team after 10 months out injured in tonight's Premier League match against Watford.
The Englishman's inclusion, with Maarten Stekelenburg injured, is one of five changes made by Ronald Koeman from the Saints' last league match, a 1-0 defeat at Norwich City.
Cedric Soares, Oriol Romeu, Matt Targett and Sadio Mane are the other players back in the starting XI.
Visitors Watford, meanwhile, make just the one change from the 2-1 defeat to Manchester City.
It comes in defence, with Sebastian Prodl preferred to Craig Cathcart at centre-back.
Southampton: Forster; Cedric, Fonte, Van Dijk, Targett; Clasie, Romeu; Davis, Mane, Bertrand; Long
Subs: Davis, Yoshida, Tadic, Martina, Ward-Prowse, Pelle, Juanmi
Watford: Gomes; Nyom, Britos, Prodl, Holebas; Capoue, Watson; Abdi, Deeney, Jurado; Ighalo
Subs: Arlauskis, Cathcart, Paredes, Behrami, Guedioura, Anya, Ibarbo
