Newcastle vs. Bournemouth (Saturday, 12.30pm)
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Two in-form Premier League teams battling for Champions League qualification square off at St James Park' on Saturday lunchtime as Newcastle United play host to Bournemouth.
The Magpies and the Cherries meet for the first time since the end of August last year when they played out a 1-1 draw at the Vitality Stadium.
We say: Newcastle United 2-1 Bournemouth
Four of the last five Premier League meetings between Newcastle and Bournemouth have ended level, and another closely-fought contest could be on the cards this weekend.
As impressive as Bournemouth have been this season, it is hard to ignore Newcastle's sensational winning streak, as well as the prolific form of Isak, so we are backing the Magpies to collect another three points in front of a fired-up St James' Park crowd.
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Brentford vs. Liverpool (Saturday, 3.00pm)
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Aiming for their first Premier League win of 2025 at the third attempt, leaders Liverpool face a taxing trip to the Gtech Community Stadium to meet Brentford on Saturday afternoon.
Arne Slot's men could only manage a 1-1 draw with title rivals Nottingham Forest on Tuesday evening, but the Bees' 2-2 stalemate with Manchester City was undoubtedly one point gained rather than two dropped.
We say: Brentford 1-2 Liverpool
Goals at both ends are almost always a guarantee at the Gtech Community Stadium, where Brentford should sense an opportunity against a Liverpool side who have failed to carry their 2024 ruthlessness into 2025 so far.
However, Slot is not short of options for change whatsoever, and Brentford still have not kept a single clean sheet at home this season, so the Reds should be able to fight fire with fire and get their title pursuit back on track.
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Leicester vs. Fulham (Saturday, 3.00pm)
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Relegation-threatened Leicester City welcome European hopefuls Fulham to the King Power Stadium for a Premier League clash on Saturday afternoon.
The Foxes and the Cottagers butt heads for the first time since the end of August when the latter secured a 2-1 victory at Craven Cottage.
We say: Leicester City 1-3 Fulham
The fact that Fulham have kept just one clean sheet in their last 10 Premier League games should give Leicester confidence of ending their three-game goal drought on home soil this weekend.
However, their defensive frailties remain a concern and we are backing the Cottagers, who boast a strong head-to-head record against the Foxes, to outscore their opponents en route to collecting all three points at the King Power.
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West Ham vs. Crystal Palace (Saturday, 3.00pm)
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Two Premier League teams looking to win back-to-back games lock horns at the London Stadium on Saturday afternoon as West Ham United play host to Crystal Palace.
The Eagles will be seeking revenge against the Hammers after they suffered a 2-0 defeat in the reverse fixture at Selhurst Park at the end of August last year.
We say: West Ham United 2-2 Crystal Palace
Fourteen of the last 15 Premier League meetings between West Ham and Crystal Palace have seen both teams score, with three or more goals scored on 10 of those occasions, so goalmouth action at both ends can be expected this weekend.
The Hammers and the Eagles both have reason to be confident of success here, but there is little to separate these two teams, so an entertaining score draw could be on the cards in East London.
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Arsenal vs. Aston Villa (Saturday, 5.30pm)
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Seeking another scalp at his former stomping ground, Aston Villa head coach Unai Emery takes his Lions side to the Emirates to face Arsenal in Saturday evening's Premier League contest.
Both sides were victorious in the midweek round of matches, as the Gunners claimed a critical 2-1 North London derby win over Tottenham Hotspur, while Villa subjected David Moyes to a 1-0 loss on his Everton homecoming.
We say: Arsenal 1-1 Aston Villa
Arsenal's beating of Spurs in midweek might have been merited, but the lack of a clinical striker is still sticking out like a sore thumb, and they may not create such a large volume of chances against a more defensively-sound Aston Villa outfit.
The Gunners should not be in any danger of losing their unbeaten home league record, but Emery's in-form side are more than capable of taking a point back to Villa Park as Arsenal are sent crashing back down to earth.
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Find out more about upcoming fixtures, odds and offers in our guide to Premier League betting sites.