Laura Harvey has confirmed that she will be leaving Arsenal Ladies next month to take over at new American side Seattle Reign.
The 32-year-old has managed Arsenal since 2010, and was previously a first-team coach with the club.
Harvey told the club's website: "I've had a wonderful four-and-a-half years and would like to thank everyone at the club for the fantastic support.
"A special thanks must go to [general manager] Vic Akers for giving me the opportunity to manage this special club.
"It was always going to be a huge challenge taking over from such a legendary figure in the women's game but I've learnt so much from Vic and can't thank him enough for all that he's done for me."
She has led Arsenal to three league titles, two continental cups and the FA Women's Cup.
Seattle Reign was founded last month, and will compete in the National Women's Soccer League from next year.