Bayern vs. Augsburg (Saturday, 2.30pm)
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Seeking to bounce back from their midweek Champions League defeat, Bayern Munich play host to Bavarian rivals Augsburg at the Allianz Arena on Saturday afternoon.
Die Fuggerstadter claimed a surprise triumph in the reverse fixture against the perennial Bundesliga winners, securing a 2-1 victory in November last year.
We say: Bayern Munich 3-1 Augsburg
Given Augsburg's form and most recent win against Bayern, they will fancy their chances at the Allianz Arena, and another victory this weekend would all but secure their Bundesliga status.
However, the hosts will be fired up to not only bounce back from their midweek defeat, but to also get revenge against Die Fuggerstadter, and Nagelsmann's men should have all the resources to claim maximum points on home soil.
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Wolfsburg vs. Arminia Bielefeld (Saturday, 2.30pm)
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Two Bundesliga teams struggling at the wrong end of the table will lock horns at the Volkswagen Arena on Saturday afternoon, as Wolfsburg play host to Arminia Bielefeld.
The visitors currently sit 16th in the table, occupying the relegation playoff position, while the hosts are sitting five points and two places above them in 14th.
We say: Wolfsburg 1-0 Arminia Bielefeld
Both Wolfsburg and Arminia have struggled for form in recent weeks, and a victory for either side on Saturday could be crucial in their quest to survive.
A closely-fought contest is set to be played out at the Volkswagen Arena, but we can see the hosts securing a slender victory.
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FC Koln vs. Mainz 05 (Saturday, 2.30pm)
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FC Koln and Mainz 05 will both be looking to bounce back from Bundesliga defeats when they lock horns at the RheinEnergieStadion on Saturday afternoon.
The hosts have won only four of their last eight league fixtures on home soil, while the visitors have won only two of their last 15 matches on the road and they are yet to win an away game in 2022.
We say: FC Koln 2-1 Mainz 05
Both sides will be keen to return to winning ways as they look to end the campaign on a high by securing at least a top-half finish.
The visitors have struggled away from home for some time, and although they were victorious in their last visit to Koln, we feel that the hosts will do enough to claim all three points, especially if Modeste is fit to lead the line.
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Greuther Furth vs. Borussia M'bach (Saturday, 2.30pm)
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Basement club Greuther Furth will be looking to end their six-game winless run in the Bundesliga when they welcome Borussia Monchengladbach to the Stadion am Laubenweg on Saturday afternoon.
Furth have conceded 70 goals so far this season, the joint-most across Europe's top-five leagues along with French side Bordeaux, while Monchengladbach have the third-worst defensive record in the Bundesliga, conceding 52 goals so far this term.
We say: Greuther Furth 2-4 Borussia Monchengladbach
With two defensively vulnerable sides locking horns on Saturday, goals are to be expected at the Stadion am Laubenweg.
Although Furth will fancy their chances of finding the back of the net, having scored in eight of their last 10 matches, Monchengladbach are the favourites to come out on top and they should have enough firepower to outscore their opponents.
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Hertha Berlin vs. Union Berlin (Saturday, 5.30pm)
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Seeking a third derby win of the season, Union Berlin visit Hertha Berlin's iconic Olympiastadion on Saturday evening.
The capital city clash pits together two sides experiencing differing fortunes, with the hosts battling to avoid the drop and their visitors in the mix for European qualification.
We say: Hertha Berlin 1-2 Union Berlin
Following recent encounters, Union now hold the edge in this local affair - particularly given Hertha's ongoing woes at the back, which are set to be exacerbated by absences this weekend.
For that reason, the visitors can come out on top for a third straight Berlin derby; pushing their rivals one step closer to demotion.