La Liga 2021-22 Head-to-Head
Top Six
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Barcelona | 10 | 6 | 0 | 4 | 19 | 13 | 6 | 18 |
| 2 | Atletico MadridAtletico | 10 | 5 | 3 | 2 | 19 | 14 | 5 | 18 |
| 3 | Real Madrid | 10 | 5 | 3 | 2 | 11 | 7 | 4 | 18 |
| 4 | Villarreal | 10 | 4 | 4 | 2 | 15 | 10 | 5 | 16 |
| 5 | Real BetisBetis | 10 | 2 | 2 | 6 | 7 | 13 | -6 | 8 |
| 6 | Real Sociedad | 10 | 1 | 2 | 7 | 9 | 23 | -14 | 5 |
Bottom Six
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| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Espanyol | 10 | 4 | 4 | 2 | 16 | 12 | 4 | 16 |
| 2 | ElcheElche | 10 | 4 | 3 | 3 | 12 | 13 | -1 | 15 |
| 3 | CadizCadiz | 10 | 3 | 4 | 3 | 11 | 11 | 0 | 13 |
| 4 | Granada | 10 | 3 | 4 | 3 | 10 | 11 | -1 | 13 |
| 5 | Levante | 10 | 3 | 3 | 4 | 17 | 16 | 1 | 12 |
| 6 | AlavesAlaves | 10 | 4 | 0 | 6 | 12 | 15 | -3 | 12 |
